The San Francisco 49ers had been at residence in Week 4 to face the Jacksonville Jaguars. Coming into the mathcup, the Niners had an ideal 3-0 report. After lacking two video games as a result of toe and shoulder accidents, Brock Purdy returned in Week 4.
He was 22-38 for 309 passing yards, two touchdowns, and two interceptions. San Francisco took their first lack of the season, 26-21, to the Jaguars. On Monday afternoon, NFL insiders reported that 49ers’ Brock Purdy is coping with soreness in his toe. The Niners have a brief week with a recreation on Thursday evening in opposition to the Rams. Purdy may miss his third recreation of the season if he’s unable to play.
Brock Purdy is coping with a lingering toe damage early within the 2025 season
#49ers QB Brock Purdyy got here in “complaining of some soreness in his toe” as we speak, in line with Kyle Shanahan. Purdy and Shanahan talked on the cellphone final evening. Purdy stated he had no points throughout the recreation.
— Nick Wagoner (@nwagoner) September 29, 2025
After a 17-13 win in Week 1 vs. the Seahawks, 49ers’ Brock Purdy was coping with shoulder and toe accidents. The 25-year-old missed two straight video games for San Francisco. Backup QB Mac Jones began in Weeks 2 and three, serving to lead the 49ers to wins. Days forward of their Week 4 matchup, QB Brock Purdy was cleared to return. He began for the staff in Week 4, however San Francisco misplaced 26-21.
On Monday, NFL insider Nick Wagoner reported that Brock Purdy was complaining of soreness in his toe. Head coach Kyle Shanahan spoke with Purdy, and the QB stated he had no points throughout the recreation. The staff is already coping with a number of accidents on offense. San Francisco can’t afford for Brock Purdy to overlook any time.
Brock Purdy has 16 interceptions in his final 17 begins#49ers pic.twitter.com/Os4Y1ZJvCi
— Chase Senior (@Chase_Senior) September 29, 2025
The staff has a fast turnaround in Week 5. They’re on the highway for Thursday Evening Soccer vs. the Los Angeles Rams. If Purdy is unable to play, Mac Jones will make his third begin of the 2025 season. That’s an vital divisional matchup within the NFC West. San Francisco is 2-0 within the division this season with wins in opposition to the Seahawks and Cardinals.
Throughout their Week 4 loss to the Jaguars, WR Ricky Pearsall suffered a knee damage. Kyle Shanahan expressed optimism for Pearsall long-term, however the younger WR could possibly be out in Week 5 vs. the Rams. Moreover, George Kittle is on the IR and isn’t eligible for return till Week 6. Will Brock Purdy be obtainable in Week 5 for the 49ers? Their franchise QB is coping with a lingering toe damage that he suffered in Week 1.